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Biography

Dr Joy Varghese is a Program Co-Director for the Centre for Liver Diseases & Transplantation and Clinical Lead - Liver Intensive Care Unit in Apollo hospital, Greams road, Chennai. He is the Senior Consultant & In-charge for Transplant hepatologist for Apollo hospitals (Southern region), India.

He is a visiting consultant hepatologist & liver transplant physician and a member of teaching faculty in Department of Hepatology, Govt. General Hospital, Chennai and Institute of Liver Transplantation in Govt. Stanley Medical College Hospital, Chennai.

He has played a vital role in setting up cadaver liver transplant program in various hospitals in Tamil Nadu and Kerala states in both Government & Non-Government hospitals.

He is an examiner for National Board Examination (Gastroenterology - Speciality). He has published more than 50 research articles in the field of hepatology/liver transplantation in the indexed journals and written book chapters.  He has been serving as an editorial board member of World Journal of Hepatology and Global Journal of Gastroenterology & Hepatology and reviewer board member for various International & National journals.

He worked as the Program Director for Fellowship in Hepatology course for 3 years at Gleneagles Global Health City, affiliated with The Tamilnadu Dr M.G.R. Medical University, Chennai, India.

He received a fellowship in transplant hepatology at University Hospital, Essen, Germany. In his earlier career, he worked as assistant professor in Amrita Institute of Medical Sciences & Reseach Centre, Kochi. Then, he joined as Consultant Hepatologist & Liver transplant physician in Global hospital & health city, Chennai and has been directly involved in more than 500 adult liver (both cadaver & living donor) transplant peri-operative and long-term management.

He has vast experience in managing both transplant & non-transplant intensive care unit (Liver ICU) patients. He is one of the very few initiators in the World for therapeutic plasma exchange role in liver disease management. His goal is to set up (i) integrated acute liver failure unit and (ii) exclusive liver medical ICU which will extend its service beyond the boundary with the help of good team & advanced scientific system.

Publications

a) Original articles:

  1. Varghese J, Balan N, Naveen B, Caroline Selvi, Jayapalan K, Jayanthi V.  Does autonomic dysfunction in cirrhosis liver influence variceal bleed?  Annals of  Hepatology 2007;6(2):104-107.
  1. Varghese J, Jijo V, Rajkumar Solomon, Jayanthi V. Predictors of variceal bleed among patients with liver cirrhosis in the era of sclerotherapy. Singapore Med J 2008;49(3):239-242
  1. Udayakumar N, Subramaniam K, Umasanker L, Varghese J, Jayanthi V.Predictors of mortality in hepatic encephalopathy in acute and chronic liver disease: A preliminary observation. J Clini Gastroenterol 2007;41(2):922-926.
  1. Assessment of allograft fibrosis by transient elastography and non-invasive biomarker scoring systems in liver transplant patients. Beckebaum S, Iacob S, Klein C, Duchene A, Varghese J. Transplantation 2010; 89(8):983-993.
  1. Veena B, Rajesh G, Varghese J, Sundaram KR, Balakrishnan V. Alcoholic chronic pancreatitis and alcoholic liver cirrhosis - differences in alcohol use habits and patterns in Indian subjects. Pancreas 2012.
  1. Somasundaram A, Loganathan N, Varghese J, Singh S, Jayanthi V. Does leptospirosis behave adversely in cirrhosis of the liver? Indian Journal of Gastroenterology 2014. (PMID 25239730)
  1. Srinivas R, Olithselvan A, Varghese J, Naresh S, Rela M. Latent Mycobacterium Tuberculosis Infection in Liver Transplant Recipients – Controversies in Current Diagnosis and Management. Journal of Clinical and Experimental Hepatology 2011; 1(1):34-37.
  1. Varghese J, Gomathy N, Rajasekhar P, Venugopal K, Olithselvan A, Vivekanandan S, Naresh S, Sujatha C,  Vijaya S, Jayanthi V, Rela M. Peri-operative bacterial infection in Deceased Donor and Living Donor liver transplant patients. Journal of Clinical and Experimental Hepatology 2012;2:35-41
  2. Varghese J, Reddy S, Venugopal K, Perumalla R, Narasimhan G, Olithselvan A, Vivekanandan S,  Shanmugam N,  Vijaya S,  Jayanthi V, Rela M. Tacrolimus related adverse effects in liver transplant recipients: Its association with trough concentrations. Indian Journal of Gastroenterology 2014.
  3. Varghese J, Reddy S, Cherian T, Vijaya S,  Jayanthi V, Rela M. Anti HBs response to Hepatitis B immunoglobulin (HBIG) prophylaxis in Liver Transplant Recipients. Indian Journal of Gastroenterology 2014.
  1. Deepti S, Varghese J, Joseph J, Vijaya S, Jayanthi V, Rela M. HBsAg positive patient characteristics in hospital and blood donation camps. ISRN Hematology 2013
  1. Rajesh R, Reddy MS, Anand B, Venugopal K, Cherian T, Varghese J, the Selective policy of inferior right hepatic vein reconstruction in right lobe living donor liver transplantation does not affect post-transplant graft outcomes. Journal of Clinical and Experimental Hepatology 03/2013;3(1):S115-116
  1. Rao PN, Koshy A, Philip J, Premalatha N, Varghese J, Narayasamy K, Mohindra S, Vikas Pai, Agarwal M, Konar A, Vora H. Pegylated IF alpha 2b with Ribavirin in chronic hepatitis C. World Journal of Hepatology 2014; 6(7): 520-526
  1. Srinivas M, Srinivasan V, Mohan MB, Varghese J, Jayanthi V. A study of gender-wise risk association between fatty liver and metabolic syndrome components (Asia-Pacific criteria) ina South Indian urban cohort. Indian Journal of Gastroenterology 2015
  1. Kaliamoorthy I, Reddy M, Rajkumar A, Varghese J, Pandey S, Pillai B, Michael JC, Kancherala R, Rela M. Safe emergency evacuation of a Tertiary care hospital during the “once in a century” floods in Chennai, India. IJCCM 2016;20(2):104-108.
  1. Rajakumar A, Gupta S, Malleeswaran S, Varghese J, Kaliamoorthy I, Rela M. Anesthesia and intensive care for simultaneous liver-kidney transplantation: A single centre experience with 12 recipients. IJA 2016;60(7):38-45.
  2. Varghese J, Kedarisetty CK, Jayanthi V, Srinivasan V, Deepashree T, Uthappa MC, Ilankumaran K, Govil S, Reddy MS, Rela M. Combination of TACE and sorafenib improves outcomes in BCLC stages B/C of Hepatocellular carcinoma: A single centre experience. Annals of Hepatology 2017;16(2):247-254
  3. Shah SR, Rao PN, Sarin SK, Chowdhury A, Bhatia S, Dharamsi R, Goswami BD, Kapoor D, Luaia R, Mehta R, Mukewar S, Prasad VGM, RoopRai R, Saigal S, Singh D, Trehanpati N, Chen S, Gaggar A, Knox SJ, Subramanian GM, Singh SP, Sood A, Varghese J, Venugopal RJ. Chronic Hepatitis C virus Infection in India: Regional Demographics and Distribution of Viral Genotypes. Indian Journal of Gastroenterology 2016;35(6):467-477.
  1. Jayanthi V, Sarika S, Varghese J, Vaithiswaran V, Sharma M, Reddy MS, Vijaya S, Rela M, Kalkura S. Composition of gallbladder bile in healthy individuals and patients with gallstonedisease from the north and south
  2. Varghese J, Jayanthi V, Deepti S, Kaliyamoorthy I, Reddy MS, Vijaya S, Rela M. Therapeutic Plasma Exchange (TPE) as an adjuvant to supportive management in ESLD patients awaiting a liver transplant. Hepatology 2017 (under review)
  1. Ashwin, Sanjay Govil, Venugopal, Varghese J, Reddy MS, Rela M. Changing pattern of biliary complications in an evolving liver transplant unit. Liver Transplantation 2017
  1. Reddy MS, Kaliamoorthy I, Rajkumar A, Malleawaran S, Appusamy E, Lakshmi S, Varghese J, Rela M. Double-Blind Randomized Controlled Trial of Routine Peri-operative Use of Terlipressin in Adult Living Donor Liver Transplantation. Liver Transplantation 2017:23(8);1007-1014
  1. An Insight Into Antibiotic Resistance To Bacterial Infection In Chronic Liver Disease. Jain M, Varghese J, Micheal T, Kedarishetty CK, Swaminathan S, Jayanthi V. IJG 2017 (In press)

 

b) Review articles:

  1. Jijo V, Varghese J, Rajesh N, Jayanthi V. ERCP in acute pancreatitis – A review. HBPD International 2007; 6(3):233-240.
  2. Varghese J, Haseeb I, Ravi Shanker D, Kumar S, Jayanthi V. Hepatopulmonary syndrome – The Past to Present. Annals of Hepatology 2007; 6(3):135-142.
  3. Varghese J, Mettu S Reddy, Jayanthi V, Rela M. Management of Hepatitis B virus infection in Liver transplant Recipient. European Medical Journal- Hepatology 2013; 1:92-99
  1. Mettu S Reddy, Varghese J, Jayanthi V, Rela M. Matching donor to recipient in liver transplantation - Relevance in clinical practice. World Journal of Hepatology 2014
  1. Jayanthi V, Mayank Jain, Mukul V, Varghese J. Natural history of non-cirrhotic portal fibrosis – A tropical experience. Gastroenterol Hepatol Open Access 2017, 6(2):00185

 

c) Case reports:

  1. Varghese J, Rajesh N, Vimalraj V, Rajesh R, Jijo V, Jeswanth S, Rajagopal Jayanthi
  2. A rare cause for recurrent cystitis.  Postgraduate Medical Journal 2006;82:e11
  1. Varghese J, Jayanthi V. Paraesophageal hernia. Canadian Medical Association Journal 2007;2(1):176
  1. Varghese J, Loganathan N, Selvakumar E, Madhan P, Rajendran S, Jayanthi
  1. Portomesenteric venous gas. The New Zealand Medical Journal. Vol 119 No 1246 
  1. Varghese J, Rajesh R, Balaji AR, Rajesh N, Jijo V, Dhanpal V, Jayanthi V. Unusual  cause for chronic ascites. Netherland J Medicine 2007
  1. Varghese J, Prabhu R, Madhusoodhanan, Rajkumar S, Jayanthi V.Complication of a ventriculoperitoneal shunt. Infectious disease in Clinical Practice 2007; 16(2):120-121.
  1. Varghese J, Mohan K.R., Haseeb I, Krishnaprasad K, Sundaram A, Jayanthi V. Inflammatory Bowel Disease – Is It a Gynaecological Premalignant Lesion? A Case Report. Hungarian Medical Journal 2008; 2(2):261-264
  1. Prabhu PR, Cherian JV, Varghese J, Gunaseelan KR, Murali A, Jayanthi V. Inguinal Metastasis in gastric cancer – a path less trodden. Gastrointest Cancer Res.2008;2(2):102.
  1. Varghese J, Balakrishnan V, Narayanan V. Tracheoesophageal fistula. International Journal of Emergency Medicine 2010
  2. Varghese J, Balakrishnan V, Sadasivan S, Nair P, Narayanan V. Muscle cell membrane damage by very low serum sodium. Pan African Medical Journal 2009;3:14.
  1. Varghese J, Jayanthi V, Patra S, Rela M. A Rare Cause of Fulminant Hepatic Failure. Journal of Clinical and Experimental Hepatology 2012:2;286-288
  1. Susan G, Varghese J, Sujatha C, Rajasekar P, Jayanthi V, Rela M. Gram negative bacteria causing infective endocarditis – Rare cardiac complication after liver transplantation. World Journal of Hepatology 2013.  
  1. Naresh S, Rajasekar P, Gopinath GP, Olith S, Varghese J, Dharmesh K, Rela M. Auxiliary liver transplantation: A form of Gene therapy in selective metabolic disorders. Journal of Clinical and Experimental Hepatology 2011; 1(2):118-120.
  1. Sushma P, Mukul VJ, Varghese J, Rela M. Aggressive Primary hyperoxaluria involving the liver, hepatic artery and gallbladder in an adult. Liver International 2012
  1. An acute hemolytic transfusion reaction due to the “anti-C” rhesus antibody: A case report emphasizing the role of transfusion medicine. Asian Journal of Transfusion Medicine Jan 2015;9(2):213-215. DOI: 10.4103/0973-6247.154256
  1. Hanchanale P, Jain M, Varghese J, Jayanthi V, Rela M. Nocardia Liver Abscess in post liver transplantation- A rare presentation. Transplant Infectious disease 2017:19(2);e12670
  1. Pancreatitis, panniculitis, polyarthritis- a rare triad. Archives of Clinical Gastroenterology 2016
  2. Hepatitis C induced low-grade lymphoma with complete resolution on oral antiviral therapy. Mayank J, Varghese J, Jayanthi V. J Hepatol Gastroenterol 2017:1;001

 d) Letter to Editor:

  1. Varghese J, Krishnaprasad K, Ragul Upadhuyay, Revathy M.S, Jayanthi V.     Lipoprotein profile in cirrhosis of the liver. European Journal of Gastroenterology & Hepatology 2007;19(6):521-522.
  1. Varghese J, Thiravia MA, Natarajan B, Venkataraman J. Critical flicker test: yet another tool for minimal hepatic Encephalopathy. Eur J Gastroenterol Hepatol. 2007 Nov;19(11):1031.
  1. Varghese J, Udayakumar N, Jayanthi V. Clinical pattern of elderly cirrhosis: an Indian experience. Eur J Gas & Hepatology 2007;19(11):1031
  1. Denny ED, Ashok L, Varghese J, Jayanthi V. Predictive role of endoscopy in dysphagia with associated symptoms. Digestive Endoscopy 2008;20(1):51 
  1. Rajesh Natrayan, Varghese J, Jayanthi V. Can pain be an optional inclusion criterion for irritable bowel syndrome? Hungarian Medical Journal 2001
  1. Luke AMJ, Mathew S, Varghese J. Post-Exposure Prophylaxis What Every Dental Personnel Should Know. World Journal of Dentistry 2011;2(2):169-174
  1. Varghese J, Jayanthi V, Rela M. Mortality associated with carbapenem-resistant Klebsiella pneumonia infections in liver transplant recipients. Liver Transplantation 2012:18;1124

 

BOOK CHAPTERS:

  1. Pathophysiology of Cholestatic liver disease: Recent Developments. Jayanthi V, Varghese J, Rela M. Cholestatic Liver Diseases 2013
  2. Drug Induced Hepatitis – Current Concept. Varghese J, Jayanthi V, Rela M. Recent Advances in Hepatology 2013.

Editorial Board Member

  1. World Journal of Hepatology
  2. Global Journal of Gastroenterology & Hepatology

Invited Reviewer

  1. Indian Journal of Gastroenterology
  2. World Journal of Hepatology

Member of the Societies:

     a) Association of Physician of India

     b) Indian Society of Gastroenterology

     c)  Indian Association for Study of Liver Disease 

     d) International Club of Ascites

     e) European Association for Study of Liver Disease

     f) International Liver Transplantation Society

 

  • ISG Tamilnadu Chapter - Governing Council Member 2014 – 2015
  • ISG Tamilnadu Chapter – Treasurer 2017 – 2018

 

Organising committee member in MCLD 2014 (Master Class in Liver Disease 2014) – Perioperative care in Liver Transplantation, Jan 29th – 31st in Leela Palace, Chennai

Organising committee member in MCLD 2015 (Master Class in Liver Disease 2015) – Practice in Living Donor Liver Transplantation, Jan 28th to 31st in ITC Grand Chola, Chennai

Work Experience
  1. Einthoven prize in Electrocardiology - First prize out of 70 MD postgraduate students

  2. Association of Physician of India (A.P.I.) Medal in M.D. (Internal Medicine)

  3. Levy Thomson Award for clinical research work on “Understanding pathophysiology of hyperventilation in Cirrhosis” – Received at Canadian Digestive Disease Week, Banff, Canada in 2007.

  4. Indo – British “Young Investigator Award” – for clinical research work on “Hyperimmune plasma in Post Liver Transplantation”.

  5. ISG 2012 – Om Prakash Award for outstanding research work in the field of Gastroenterology – Received at ISGCON 2012 at Jaipur.

Oral presentation - ‘Time to do Liver Transplantation’ in 18th World Congress of International Associations of Surgeons, Gastroenterologist & Oncologist on 8th - 11th October 2008 at Istanbul, Turkey.

Invited speaker - Pan-African Network Medical Symposium on 8th September 2009 – Invited speaker – to deliver lecture on – Portal Hypertension

Invited speaker – Current Concepts in HBV Management in Post liver Transplantation - World Congress of Virology 2010 at Busan, South Korea

Invited speaker – Liver Transplantation in Liver / Non-Liver Diseases - Gastroenterological and Digestive Endoscopy Society of Sri Lanka 2010 at Colombo, Sri Lanka

Invited speaker – When to refer the patient for liver transplantation? – National Medical Conference at Baghdad, Iraq on 11.12.2013

Invited speaker – NASH and Liver Transplantation – 3rd Myanmar GI & Liver International Scientific Meeting, at Yangon, Myanmar on 08.03.2014